5cpr: Difference between revisions
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The | ==The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity== | ||
<StructureSection load='5cpr' size='340' side='right' caption='[[5cpr]], [[Resolution|resolution]] 2.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cpr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CPR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=539:6,7-DICHLORO-N-CYCLOPENTYL-4-(PYRIDIN-4-YL)PHTHALAZIN-1-AMINE'>539</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cpr OCA], [http://pdbe.org/5cpr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cpr RCSB], [http://www.ebi.ac.uk/pdbsum/5cpr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cpr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SV421_HUMAN SV421_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Jakob, C G]] | |||
[[Category: Sun, C]] | |||
[[Category: Upadhyay, A K]] | |||
[[Category: H4k20]] | |||
[[Category: Non-homologous end joining]] | |||
[[Category: Protein lysine transferase]] | |||
[[Category: Transferase]] | |||
Revision as of 23:38, 25 January 2017
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
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