5dry: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5dry is ~~ON HOLD until Paper Publication~~

==Crystal structure of Dot1L in complex with inhibitor CPD3 [N-(1-(2-chlorophenyl)-1H-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1H-tetrazol-1-yl)acetyl)hydrazinecarboxamide]==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5dry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DRY FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5EK:N-[1-(2-CHLOROPHENYL)-1H-INDOL-6-YL]-2-{[5-(2-CHLOROPHENYL)-1H-TETRAZOL-1-YL]ACETYL}HYDRAZINECARBOXAMIDE'>5EK</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dry OCA], [http://pdbe.org/5dry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dry RCSB], [http://www.ebi.ac.uk/pdbsum/5dry PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

__TOC__

</StructureSection>

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Be, C]]

[[Category: Gaul, C]]

[[Category: Moebitz, H]]

[[Category: Scheufler, C]]

[[Category: Complex]]

[[Category: Inhibitor]]

[[Category: Methyltransferase]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5dry is ON HOLD  until Paper Publication
+==Crystal structure of Dot1L in complex with inhibitor CPD3 [N-(1-(2-chlorophenyl)-1H-indol-6-yl)-2-(2-(5-(2-chlorophenyl)-1H-tetrazol-1-yl)acetyl)hydrazinecarboxamide]==
+<StructureSection load='5dry' size='340' side='right' caption='[[5dry]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5dry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DRY FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5EK:N-[1-(2-CHLOROPHENYL)-1H-INDOL-6-YL]-2-{[5-(2-CHLOROPHENYL)-1H-TETRAZOL-1-YL]ACETYL}HYDRAZINECARBOXAMIDE'>5EK</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dry OCA], [http://pdbe.org/5dry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dry RCSB], [http://www.ebi.ac.uk/pdbsum/5dry PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
+__TOC__
+</StructureSection>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Be, C]]
+[[Category: Gaul, C]]
+[[Category: Moebitz, H]]
+[[Category: Scheufler, C]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Methyltransferase]]
+[[Category: Transferase]]