5fg0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5fg0 is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of the conserved yeast listerin (Ltn1) N-terminal domain, MONOCLINIC FORM==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5fg0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG0 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FG0 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5fg1|5fg1]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg0 OCA], [http://pdbe.org/5fg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg0 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/LTN1_YEAST LTN1_YEAST]] E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).<ref>PMID:17283062</ref> <ref>PMID:20835226</ref> <ref>PMID:23178123</ref> <ref>PMID:23825054</ref> <ref>PMID:24261871</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Doamekpor, S K]]

[[Category: Lima, C D]]

[[Category: Ligase]]

[[Category: Protein quality control]]

[[Category: Ribosome]]

[[Category: Ubiquitin ligase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5fg0 is ON HOLD  until Paper Publication
+==Structure of the conserved yeast listerin (Ltn1) N-terminal domain, MONOCLINIC FORM==
+<StructureSection load='5fg0' size='340' side='right' caption='[[5fg0]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fg0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FG0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fg1|5fg1]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fg0 OCA], [http://pdbe.org/5fg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fg0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fg0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fg0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/LTN1_YEAST LTN1_YEAST]] E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product (PubMed:20835226, PubMed:23825054, PubMed:24261871). May indirectly play a role in chromatin function and transcription (PubMed:17283062).<ref>PMID:17283062</ref> <ref>PMID:20835226</ref> <ref>PMID:23178123</ref> <ref>PMID:23825054</ref> <ref>PMID:24261871</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Doamekpor, S K]]
+[[Category: Lima, C D]]
+[[Category: Ligase]]
+[[Category: Protein quality control]]
+[[Category: Ribosome]]
+[[Category: Ubiquitin ligase]]