5hl1: Difference between revisions
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==Crystal structure of glutaminase C in complex with inhibitor CB-839== | |||
<StructureSection load='5hl1' size='340' side='right' caption='[[5hl1]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hl1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HL1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63J:2-(PYRIDIN-2-YL)-N-(5-{4-[6-({[3-(TRIFLUOROMETHOXY)PHENYL]ACETYL}AMINO)PYRIDAZIN-3-YL]BUTYL}-1,3,4-THIADIAZOL-2-YL)ACETAMIDE'>63J</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fi2|5fi2]]</td></tr> | ||
[[Category: Cerione, R | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hl1 OCA], [http://pdbe.org/5hl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hl1 RCSB], [http://www.ebi.ac.uk/pdbsum/5hl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hl1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Glutaminase]] | |||
[[Category: Cerione, R A]] | |||
[[Category: Huang, Q]] | [[Category: Huang, Q]] | ||
[[Category: Cb-839]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 06:51, 10 September 2016
Crystal structure of glutaminase C in complex with inhibitor CB-839
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