5hml: Difference between revisions
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==Crystal Structure of T5 D15 Protein Co-crystallized with Metal Ions== | |||
<StructureSection load='5hml' size='340' side='right' caption='[[5hml]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hml]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HML FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_(lambda-induced) Exodeoxyribonuclease (lambda-induced)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.3 3.1.11.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hml OCA], [http://pdbe.org/5hml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hml RCSB], [http://www.ebi.ac.uk/pdbsum/5hml PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/EXO5_BPT5 EXO5_BPT5]] 5'-exonucleolytic degradation of double-stranded (ds) DNA. Can also cleave bifurcated nucleic acids such as flap and pseudo-Y substrates in a structure-specific manner. This requires free 5' single-stranded (ss) ends and cleaves at the ds/ss junction. Binds DNA pseudo-Y substrates with a dissociation constant of 5 nM. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Artymiuk, P J]] | |||
[[Category: Feng, M]] | |||
[[Category: Flemming, C S]] | |||
[[Category: Rafferty, J B]] | |||
[[Category: Sayers, J R]] | |||
[[Category: Sedelnikova, S E]] | |||
[[Category: Zhang, J]] | |||
[[Category: Alternative conformation]] | |||
[[Category: Flap endonuclease]] | |||
[[Category: Hydrolase]] | |||
[[Category: Metal ion complex]] | |||
