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'''CRYSTAL STRUCTURE OF P18-INK4C(INK6)''' | '''CRYSTAL STRUCTURE OF P18-INK4C(INK6)''' | ||
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[[Category: Ravichandran, V.]] | [[Category: Ravichandran, V.]] | ||
[[Category: Swaminathan, K.]] | [[Category: Swaminathan, K.]] | ||
[[Category: | [[Category: Ankyrin repeat]] | ||
[[Category: | [[Category: Cdk 4/6 inhibitor]] | ||
[[Category: | [[Category: Cell cycle inhibitor]] | ||
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Revision as of 17:00, 2 May 2008
CRYSTAL STRUCTURE OF P18-INK4C(INK6)
Overview
p18INK4c is a member of a family of INK4 proteins that function to arrest the G1 to S cell cycle transition by inhibiting the activity of the cyclin-dependent kinases 4 and 6. The X-ray crystal structure of the human p18INK4c protein to a resolution of 1.95 A reveals an elongated molecule comprised of five contiguous 32- or 33-residue ankyrin-like repeat units. Each ankyrin-like repeat contains a beta-strand helix-turn-helix extended strand beta-strand motif that associates with neighboring motifs through beta-sheet, and helical bundle interactions. Conserved ankyrin-like repeat residues function to facilitate the ankyrin repeat fold and the tertiary interactions between neighboring repeat units. A large percentage of residues that are conserved among INK4 proteins and that map to positions of tumor-derived p16INK4 mutations play important roles in protein stability. A subset of these residues suggest an INK4 binding surface for the cyclin-dependent kinases 4 and 6. This surface is centered around a region that shows structural features uncharacteristic of ankyrin-like repeat units.
About this Structure
1IHB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations., Venkataramani R, Swaminathan K, Marmorstein R, Nat Struct Biol. 1998 Jan;5(1):74-81. PMID:9437433 Page seeded by OCA on Fri May 2 20:00:00 2008
