5icv: Difference between revisions
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==Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue== | |||
<StructureSection load='5icv' size='340' side='right' caption='[[5icv]], [[Resolution|resolution]] 1.53Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5icv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ICV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XE:[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)furan-2-yl]methyl+(3R)-4-{[3-({(E)-2-[(2,2-dihydroxyethyl)sulfanyl]ethenyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl+dihydrogen+diphosphate'>1XE</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5icv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icv OCA], [http://pdbe.org/5icv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icv RCSB], [http://www.ebi.ac.uk/pdbsum/5icv PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NAA60_HUMAN NAA60_HUMAN]] Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.<ref>PMID:21750686</ref> <ref>PMID:21981917</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arnesen, T]] | |||
[[Category: Magin, R S]] | |||
[[Category: Marmorstein, R]] | |||
[[Category: Stove, S I]] | |||
[[Category: Acetylation]] | |||
[[Category: Gnat]] | |||
[[Category: Nat]] | |||
[[Category: Transferase]] | |||
Revision as of 23:28, 23 June 2016
Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue
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