5j6r: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5j6r is ~~ON HOLD until Paper Publication~~

==Crystal structure of Human Papillomavirus Type 59 L1 pentamer==

~~Authors~~: Li, Z.H., ~~Yan~~, X.D., Yu, H., Gu, Y., Li, S.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[5j6r]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J6R FirstGlance]. <br>

~~Description: Crystal structure of Human Papillomavirus Type 59 L1 pentamer~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6r OCA], [http://pdbe.org/5j6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6r RCSB], [http://www.ebi.ac.uk/pdbsum/5j6r PDBsum]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: Yan, X.D]]

== Function ==

[[http://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]

__TOC__

</StructureSection>

[[Category: Gu, Y]]

[[Category: Li, S W]]

[[Category: Li, Z H]]

[[Category: Yan, X D]]

[[Category: Yu, H]]

[[Category: ~~Li, Z.H~~]]

[[Category: Major structural protein]]

[[Category: ~~Gu, Y~~]]

[[Category: Pentamer]]

[[Category: ~~Li, S.W~~]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5j6r is ON HOLD  until Paper Publication
+==Crystal structure of Human Papillomavirus Type 59 L1 pentamer==
+<StructureSection load='5j6r' size='340' side='right' caption='[[5j6r]], [[Resolution|resolution]] 4.01&Aring;' scene=''>
-Authors: Li, Z.H., Yan, X.D., Yu, H., Gu, Y., Li, S.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5j6r]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J6R FirstGlance]. <br>
-Description: Crystal structure of Human Papillomavirus Type 59 L1 pentamer
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6r OCA], [http://pdbe.org/5j6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6r RCSB], [http://www.ebi.ac.uk/pdbsum/5j6r PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Yan, X.D]]
+== Function ==
+[[http://www.uniprot.org/uniprot/Q81971_HPV59 Q81971_HPV59]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00505820]
+__TOC__
+</StructureSection>
+[[Category: Gu, Y]]
+[[Category: Li, S W]]
+[[Category: Li, Z H]]
+[[Category: Yan, X D]]
 [[Category: Yu, H]]
-[[Category: Li, Z.H]]
+[[Category: Major structural protein]]
-[[Category: Gu, Y]]
+[[Category: Pentamer]]
-[[Category: Li, S.W]]
+[[Category: Viral protein]]