5jjs: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5jjs ~~is ON HOLD until Paper Publication~~

==Dengue 3 NS5 protein with compound 27==

~~Authors~~: ~~Lescar, J~~.~~, El Sahili, A~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5jjs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJS OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JJS FirstGlance].

~~Description~~: ~~Dengue~~ 3 ~~NS5 protein with compound 27~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=6L2:5-[5-(3-HYDROXYPROP-1-YN-1-YL)THIOPHEN-2-YL]-2,4-DIMETHOXY-N-{[(1R,3R)-3-METHOXYCYCLOHEXYL]SULFONYL}BENZAMIDE'>6L2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5jjr|5jjr]]</td></tr>

[[~~Category~~: ~~El Sahili~~, A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jjs OCA], [http://pdbe.org/5jjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jjs RCSB], [http://www.ebi.ac.uk/pdbsum/5jjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jjs ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]

__TOC__

</StructureSection>

[[Category: Lescar, J]]

[[Category: Sahili, A El]]

[[Category: Dengue]]

[[Category: Rdrp]]

[[Category: Transferase-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5jjs is ON HOLD  until Paper Publication
+==Dengue 3 NS5 protein with compound 27==
+<StructureSection load='5jjs' size='340' side='right' caption='[[5jjs]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors: Lescar, J., El Sahili, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5jjs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JJS FirstGlance]. <br>
-Description: Dengue 3 NS5 protein with compound 27
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6L2:5-[5-(3-HYDROXYPROP-1-YN-1-YL)THIOPHEN-2-YL]-2,4-DIMETHOXY-N-{[(1R,3R)-3-METHOXYCYCLOHEXYL]SULFONYL}BENZAMIDE'>6L2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jjr|5jjr]]</td></tr>
-[[Category: El Sahili, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jjs OCA], [http://pdbe.org/5jjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jjs RCSB], [http://www.ebi.ac.uk/pdbsum/5jjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jjs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
+__TOC__
+</StructureSection>
 [[Category: Lescar, J]]
+[[Category: Sahili, A El]]
+[[Category: Dengue]]
+[[Category: Rdrp]]
+[[Category: Transferase-inhibitor complex]]