5jqj: Difference between revisions
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==Directed evolutionary changes in MBL super family - NDM-1 Round 10 crystal-1== | |||
<StructureSection load='5jqj' size='340' side='right' caption='[[5jqj]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jqj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqj OCA], [http://pdbe.org/5jqj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jqj RCSB], [http://www.ebi.ac.uk/pdbsum/5jqj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Carr, P D]] | |||
[[Category: Hong, N S]] | |||
[[Category: Jackson, C J]] | |||
[[Category: Directed evolution]] | |||
[[Category: Hydrolase]] | |||
[[Category: Mbl super family]] | |||
[[Category: Ndm-1]] | |||
[[Category: Phosphatase]] | |||