5jul: Difference between revisions

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'''Unreleased structure'''
{{Large structure}}
==Near atomic structure of the Dark apoptosome==
<StructureSection load='5jul' size='340' side='right' caption='[[5jul]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5jul]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JUL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=APK:5-O-[(S)-{[(5S)-5-AMINO-6-OXOHEXYL]AMINO}(HYDROXY)PHOSPHORYL]ADENOSINE'>APK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jul OCA], [http://pdbe.org/5jul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jul RCSB], [http://www.ebi.ac.uk/pdbsum/5jul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jul ProSAT]</span></td></tr>
</table>
{{Large structure}}
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In Drosophila, the Apaf-1-related killer (Dark) forms an apoptosome that activates procaspases. To investigate function, we have determined a near-atomic structure of Dark double rings using cryo-electron microscopy. We then built a nearly complete model of the apoptosome that includes 7- and 8-blade beta-propellers. We find that the preference for dATP during Dark assembly may be governed by Ser325, which is in close proximity to the 2' carbon of the deoxyribose ring. Interestingly, beta-propellers in V-shaped domains of the Dark apoptosome are more widely separated, relative to these features in the Apaf-1 apoptosome. This wider spacing may be responsible for the lack of cytochrome c binding to beta-propellers in the Dark apoptosome. Our structure also highlights the roles of two loss-of-function mutations that may block Dark assembly. Finally, the improved model provides a framework to understand apical procaspase activation in the intrinsic cell death pathway.


The entry 5jul is ON HOLD
A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation.,Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW Structure. 2017 Jan 3;25(1):40-52. doi: 10.1016/j.str.2016.11.002. Epub 2016 Dec , 1. PMID:27916517<ref>PMID:27916517</ref>


Authors:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description:  
<div class="pdbe-citations 5jul" style="background-color:#fffaf0;"></div>
[[Category: Unreleased Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Akey, C W]]
[[Category: Akey, I V]]
[[Category: Cheng, T C]]
[[Category: Ludtke, S J]]
[[Category: Yu, Z]]
[[Category: Yuan, S]]
[[Category: Aaa+ atpase]]
[[Category: Apoptosis]]
[[Category: Apoptosome]]
[[Category: Apotosis]]
[[Category: Dark]]
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