5juw: Difference between revisions
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==complex of Dot1l with SS148== | |||
<StructureSection load='5juw' size='340' side='right' caption='[[5juw]], [[Resolution|resolution]] 2.28Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5juw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JUW FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6NR:(2~{S})-2-AZANYL-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-AZANYL-5-CYANO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYLSULFANYL]BUTANOIC+ACID'>6NR</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
[[Category: Bayle, E | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5juw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5juw OCA], [http://pdbe.org/5juw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5juw RCSB], [http://www.ebi.ac.uk/pdbsum/5juw PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN]] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Histone-lysine N-methyltransferase]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bayle, E D]] | |||
[[Category: Bountra, C]] | |||
[[Category: Brown, P J]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Fish, P V]] | |||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Schapira, M]] | [[Category: Schapira, M]] | ||
[[Category: | [[Category: Spurr, S S]] | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
[[Category: Weigelt, J]] | [[Category: Weigelt, J]] | ||
[[Category: Yu, W]] | |||
[[Category: Sgc]] | |||
[[Category: Transferase]] | |||
