5jvx: Difference between revisions
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==X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene compound== | |||
<StructureSection load='5jvx' size='340' side='right' caption='[[5jvx]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thaumatococcus_daniellii Thaumatococcus daniellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JVX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6O0:(1-BUTYL-3-METHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-YLIDENE)(CHLORO)GOLD'>6O0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jvx OCA], [http://pdbe.org/5jvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jvx RCSB], [http://www.ebi.ac.uk/pdbsum/5jvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jvx ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/THM1_THADA THM1_THADA]] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The X-ray structure of the adduct formed in the reaction between the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene) and the model protein thaumatin is reported here. The structure reveals binding of Au(NHC)+ fragments to distinct protein sites. Notably, binding of the gold compound occurs at lysine side chains and at the N-terminal tail; the metal binds the protein after releasing Cl- ligand, but retaining NHC fragment. | |||
First Crystal Structure for a Gold Carbene-Protein Adduct.,Ferraro G, Gabbiani C, Merlino A Bioconjug Chem. 2016 Jul 6. PMID:27364343<ref>PMID:27364343</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5jvx" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Thaumatococcus daniellii]] | |||
[[Category: Ferraro, G]] | [[Category: Ferraro, G]] | ||
[[Category: Merlino, A]] | [[Category: Merlino, A]] | ||
[[Category: Plant protein]] | |||
Revision as of 11:48, 14 July 2016
X-ray structure of the adduct formed in the reaction between thaumatin and a gold carbene compound
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