5k47: Difference between revisions
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The | ==CryoEM structure of the human Polycystin-2/PKD2 TRP channel== | ||
<StructureSection load='5k47' size='340' side='right' caption='[[5k47]], [[Resolution|resolution]] 4.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5k47]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K47 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k47 OCA], [http://pdbe.org/5k47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k47 RCSB], [http://www.ebi.ac.uk/pdbsum/5k47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k47 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/PKD2_HUMAN PKD2_HUMAN]] Defects in PKD2 are the cause of polycystic kidney disease 2 (PKD2) [MIM:[http://omim.org/entry/613095 613095]]. PKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. PKD2 is clinically milder than PKD1 but it has a deleterious impact on overall life expectancy.<ref>PMID:9326320</ref> <ref>PMID:10541293</ref> <ref>PMID:10411676</ref> <ref>PMID:10835625</ref> <ref>PMID:11968093</ref> <ref>PMID:12707387</ref> <ref>PMID:14993477</ref> <ref>PMID:15772804</ref> <ref>PMID:21115670</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PKD2_HUMAN PKD2_HUMAN]] Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). Functions as a calcium permeable cation channel. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Burgess-Brown, N A]] | |||
[[Category: Carpenter, E P]] | |||
[[Category: Chalk, R]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Grieben, M]] | |||
[[Category: Huiskonen, J T]] | |||
[[Category: Mahajan, P]] | |||
[[Category: Mukhopadhyay, S]] | |||
[[Category: Pike, A C.W]] | |||
[[Category: Structural genomic]] | |||
[[Category: Shintre, C A]] | |||
[[Category: Shrestha, L]] | |||
[[Category: Tessitore, A]] | |||
[[Category: Ion channel]] | |||
[[Category: Polycystic kidney disease]] | |||
[[Category: Sgc]] | |||
[[Category: Transient receptor potential channel]] | |||
[[Category: Transport protein]] | |||
