5k4f: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5k4f is ~~ON HOLD until Paper Publication~~

==CAL PDZ mutant C319A with a peptide==

~~Authors~~: ~~Zhao~~, Y., ~~Madden~~, D.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[5k4f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K4F FirstGlance]. <br>

~~Description~~: ~~CAL PDZ mutant C319A~~ with ~~a peptide~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4f OCA], [http://pdbe.org/5k4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k4f RCSB], [http://www.ebi.ac.uk/pdbsum/5k4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4f ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>

== Function ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> [[http://www.uniprot.org/uniprot/VE6_HPV18 VE6_HPV18]] Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.

== References ==

__TOC__

</StructureSection>

[[Category: Madden, D R]]

[[Category: Zhao, Y]]

[[Category: ~~Madden, D.R~~]]

[[Category: C319a]]

[[Category: Cal pdz mutant]]

[[Category: Peptide binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5k4f is ON HOLD  until Paper Publication
+==CAL PDZ mutant C319A with a peptide==
+<StructureSection load='5k4f' size='340' side='right' caption='[[5k4f]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
-Authors: Zhao, Y., Madden, D.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5k4f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K4F FirstGlance]. <br>
-Description: CAL PDZ mutant C319A with a peptide
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4f OCA], [http://pdbe.org/5k4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k4f RCSB], [http://www.ebi.ac.uk/pdbsum/5k4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4f ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>  [[http://www.uniprot.org/uniprot/VE6_HPV18 VE6_HPV18]] Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Madden, D R]]
 [[Category: Zhao, Y]]
-[[Category: Madden, D.R]]
+[[Category: C319a]]
+[[Category: Cal pdz mutant]]
+[[Category: Peptide binding protein]]