5l4h: Difference between revisions
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==X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)== | |||
<StructureSection load='5l4h' size='340' side='right' caption='[[5l4h]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l4h]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L4H FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6JW:5-(2-BROMOETHYL)-5-ETHYL-1,3-DIAZINANE-2,4,6-TRIONE'>6JW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4h OCA], [http://pdbe.org/5l4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4h RCSB], [http://www.ebi.ac.uk/pdbsum/5l4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4h ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Delarue, M]] | |||
[[Category: Fourati, Z]] | [[Category: Fourati, Z]] | ||
[[Category: Ruza, R | [[Category: Ruza, R R]] | ||
[[Category: | [[Category: Membrane protein]] | ||
[[Category: Transport protein]] | |||
Revision as of 21:43, 22 December 2016
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)
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