Nucleoside diphosphate kinase: Difference between revisions
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{{STRUCTURE_1nsk| PDB=1nsk | SIZE=400| SCENE= |right|CAPTION=Human nucleoside diphosphate kinase hexamer, [[1nsk]] }} | {{STRUCTURE_1nsk| PDB=1nsk | SIZE=400| SCENE= |right|CAPTION=Human nucleoside diphosphate kinase hexamer, [[1nsk]] }} | ||
== Function == | |||
'''Nucleoside diphosphate kinase''' (NDK) catalyzes the exchange of phosphate between nucleoside triphosphate and nucleoside diphosphate. This reaction is a multi-step reaction which is used for the synthesis of nucleoside triphosphates other than ATP<ref>PMID:12972261</ref>. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization. | |||
== Disease == | |||
NDKB deficiency causes diabetes-like vascular pathology<ref>PMID:25900369</ref>. | |||
==3D structures of nucleoside diphosphate kinase== | ==3D structures of nucleoside diphosphate kinase== | ||
