P63: Difference between revisions
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== Function == | == Function == | ||
'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref> | '''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref>. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. | ||
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
One isoform of P63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. Another isoform functions in apoptosis<ref>PMID:16998800</ref>. | |||
</StructureSection> | </StructureSection> | ||
