5jn0: Difference between revisions
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==CRK-II SH2 domain== | |||
<StructureSection load='5jn0' size='340' side='right' caption='[[5jn0]], [[Resolution|resolution]] 1.68Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jn0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JN0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jn0 OCA], [http://pdbe.org/5jn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jn0 RCSB], [http://www.ebi.ac.uk/pdbsum/5jn0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jn0 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cho, J H]] | |||
[[Category: Protein binding]] | |||
[[Category: Sh2 domain]] | |||
