5jy3: Difference between revisions
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==CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927== | |||
<StructureSection load='5jy3' size='340' side='right' caption='[[5jy3]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5jy3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JY3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OX:2-[2-[2-[2,6-BIS(CHLORANYL)PHENYL]PROPAN-2-YL]-1-[2-FLUORANYL-4-[3-FLUORANYL-4-(HYDROXYMETHYL)-5-METHYLSULFONYL-PHENYL]PHENYL]IMIDAZOL-4-YL]PROPAN-2-OL'>6OX</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jy3 OCA], [http://pdbe.org/5jy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jy3 RCSB], [http://www.ebi.ac.uk/pdbsum/5jy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jy3 ProSAT]</span></td></tr> | ||
[[Category: Muckelbauer, J | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Muckelbauer, J K]] | |||
[[Category: Lxr-b]] | |||
[[Category: Lxrb]] | |||
[[Category: Ner]] | |||
[[Category: Ner-i]] | |||
[[Category: Nhr]] | |||
[[Category: Nr1h2]] | |||
[[Category: Rip15]] | |||
[[Category: Transcription]] | |||
[[Category: Unr]] | |||
Revision as of 18:29, 2 November 2016
CRYSTAL STRUCTURE OF LXRbeta (NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 2) COMPLEXED WITH BMS-852927
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