5k6j: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5k6j is ~~ON HOLD~~ ~~until Paper Publication~~

==Human Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5k6j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6J OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K6J FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=6QQ:6-[[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl]oxy]-5-chloranyl-2-(4-oxidanylidenepentoxy)pyridine-3-carbonitrile'>6QQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6j OCA], [http://pdbe.org/5k6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k6j RCSB], [http://www.ebi.ac.uk/pdbsum/5k6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6j ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>

== References ==

__TOC__

</StructureSection>

[[Category: 3',5'-cyclic-AMP phosphodiesterase]]

[[Category: Rock, F L]]

[[Category: Sullivan, D]]

[[Category: Zhou, Y]]

[[Category: Hydrolase]]

[[Category: Phosphodiesterase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5k6j is ON HOLD  until Paper Publication
+==Human Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor==
+<StructureSection load='5k6j' size='340' side='right' caption='[[5k6j]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5k6j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K6J FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6QQ:6-[[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-3-yl]oxy]-5-chloranyl-2-(4-oxidanylidenepentoxy)pyridine-3-carbonitrile'>6QQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k6j OCA], [http://pdbe.org/5k6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k6j RCSB], [http://www.ebi.ac.uk/pdbsum/5k6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k6j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
+[[Category: Rock, F L]]
+[[Category: Sullivan, D]]
+[[Category: Zhou, Y]]
+[[Category: Hydrolase]]
+[[Category: Phosphodiesterase]]