5l50: Difference between revisions
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==Crystal structure of enzyme in purine metabolism== | |||
<StructureSection load='5l50' size='340' side='right' caption='[[5l50]], [[Resolution|resolution]] 1.64Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l50]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L50 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l50 OCA], [http://pdbe.org/5l50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l50 RCSB], [http://www.ebi.ac.uk/pdbsum/5l50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l50 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 5'-nucleotidase]] | |||
[[Category: Hnizda, A]] | [[Category: Hnizda, A]] | ||
[[Category: Pachl, P]] | [[Category: Pachl, P]] | ||
[[Category: Rezacova, P]] | [[Category: Rezacova, P]] | ||
[[Category: Enzyme]] | |||
[[Category: Hydrolase]] | |||
[[Category: Purine]] | |||
