Peroxiredoxin

Function

Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue.

Typical 2-Cys Prx

• Prx 1 interacts with signaling molecules.
• Prx 2 interacts with signaling molecules.
• Prx 3 interacts with signaling molecules.
• Prx 4 interacts with signaling molecules.

Atypical 2-Cys Prx

• Prx 5 interacts with signaling molecules.

1-Cys Prx

• Prx 6 interacts with signaling molecules.

Relevance

Prx are over expressed in cancer tissue.

3D Structures of Peroxiredoxin

Updated on 21-June-2016

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• Peroxiredoxin
  • 1qq2 – r2Cys-Prx – rat
    
  • 2c0d – Pf2Cys-Prx – Plasmodium falciparum
    
  • 1xiy – Pf1Cys-Prx
    
  • 1xcc, 2h01, 3tb2 - 1Cys-Prx – Plasmodium yoelii
    
  • 2i81 - 2Cys-Prx – Plasmodium vivax
    
  • 1qmv - h2Cys-Prx – human
    
  • 2a4v – yPrx dot5 C-terminal (mutant) – yeast
    
  • 3cmi – yPrx hyr1 - yeast
    
  • 4g2e – Prx – Sulfolobus tokodaii
    
  • 3sbc – yPrx Tsa1 (mutant)
    
  • 1uul - 2Cys-Prx – Trypanosoma cruzi
    
  • 1we0 – Prx – Amphibacillus xylanus
    
  • 2cv4, 2cx3, 2cx4 – Prx – Aeropyrum pernix
    
  • 3drn – SsPrx – Sulfolobus solfataricus
    
  • 3hjp – SsPrx (mutant)
    
  • 3ixr – Prx PRXQ (mutant) – Xylella fastidiosa
    
• Peroxiredoxin 1
  • 2rii, 3hy2 – hPrx 1 (mutant)+sulfiredoxin 1
    
  • 2z9s – rPrx 1 (mutant)
    
  • 4kw6, 4fh8 – Prx 1 – Ancylostoma ceylanicum
    
  • 3zl5 - mPrx 1 (mutant) – mouse
    
• Peroxiredoxin 2
  • 1tp9 – Prx II – Populus trichocarpa
    
  • 2pwj – Prx II – garden pea
    
  • 4dsq, 4dsr, 4h86, 4owy – yPrx II
    
  • 4dss – yPrx II (mutant) + thioredoxin II
    
• Peroxiredoxin 3
  • 1zye – Prx III (mutant) – bovine
    
• Peroxiredoxin 4
  • 3tjf, 3tjg, 3tjj, 3tjk, 3tkr - hPrx 4 (mutant)
    
  • 4rqx – hPrx 4 + thioethanesulfonic acid
    
  • 3qpm – Prx 4 – Larimichtys crocea
    
  • 2pn8, 3tjb, 3tkp, 3tkq, 3tks – hPrx 4
    
  • 3vwu, 3vwv - mPrx 4 (mutant)
    
• Peroxiredoxin 5
  • 1urm – hPrx 5 (mutant) – human
    
  • 2vl2, 2vl3, 2vl9, 1h4o, 1hd2, 1oc3 – hPrx 5
    
  • 3mng – hPrx 5+DTT
    
  • 4k7i, 4k7n, 4k7o, 4mmm – hPrx 5 catalytic domain + fragment
    
  • 2wfc – lPrx 5 - lugworm
    
  • 2xhf – Prx 5 – Alvinella pompejana
    
• Peroxiredoxin 6
  • 2v2g – lPrx 6
    
  • 2v32, 2v41 – lPrx 6 (mutant)
    

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Joel L. Sussman, Michal Harel