5l59: Difference between revisions
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The | ==Plexin A1 full extracellular region, domains 1 to 10, to 6 angstrom, spacegroup P2(1)== | ||
<StructureSection load='5l59' size='340' side='right' caption='[[5l59]], [[Resolution|resolution]] 6.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5l59]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L59 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l59 OCA], [http://pdbe.org/5l59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l59 RCSB], [http://www.ebi.ac.uk/pdbsum/5l59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l59 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PLXA1_MOUSE PLXA1_MOUSE]] Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.<ref>PMID:10520994</ref> <ref>PMID:10781943</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Coles, C H]] | |||
[[Category: Gilbert, R J.C]] | |||
[[Category: Janssen, B J.C]] | |||
[[Category: Jones, E Y]] | |||
[[Category: Kaufmann, R]] | |||
[[Category: Kong, Y]] | |||
[[Category: Malinauskas, T]] | |||
[[Category: Ni, T]] | |||
[[Category: Padilla-Parra, S]] | |||
[[Category: Pasterkamp, R J]] | |||
[[Category: Vangoor, V R]] | |||
[[Category: Axon guidance]] | |||
[[Category: Receptor]] | |||
[[Category: Signaling]] | |||
[[Category: Signaling protein]] | |||
Revision as of 18:05, 13 July 2016
Plexin A1 full extracellular region, domains 1 to 10, to 6 angstrom, spacegroup P2(1)
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