5l7i: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5l7i is ~~ON HOLD~~ ~~until Paper Publication~~

==Structure of human Smoothened in complex with Vismodegib==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5l7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L7I FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPG:[(Z)-OCTADEC-9-ENYL]+(2R)-2,3-BIS(OXIDANYL)PROPANOATE'>MPG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=VIS:2-CHLORANYL-~{N}-(4-CHLORANYL-3-PYRIDIN-2-YL-PHENYL)-4-METHYLSULFONYL-BENZAMIDE'>VIS</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7i OCA], [http://pdbe.org/5l7i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7i RCSB], [http://www.ebi.ac.uk/pdbsum/5l7i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7i ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Covey, D F]]

[[Category: Eamon, F X.B]]

[[Category: Hedger, G]]

[[Category: Luchetti, G]]

[[Category: Miller, P S]]

[[Category: Mydock-McGrane, L]]

[[Category: Nachtergaele, S]]

[[Category: Newstead, S]]

[[Category: Rambo, R F]]

[[Category: Rohatgi, R]]

[[Category: Sansom, M S.P]]

[[Category: Siebold, C]]

[[Category: Sircar, R]]

[[Category: Tully, M D]]

[[Category: G protein coupled receptor]]

[[Category: Hedgehog signaling]]

[[Category: Membrane protein]]

[[Category: Morphogen signaling]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5l7i is ON HOLD  until Paper Publication
+==Structure of human Smoothened in complex with Vismodegib==
+<StructureSection load='5l7i' size='340' side='right' caption='[[5l7i]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5l7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L7I FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPG:[(Z)-OCTADEC-9-ENYL]+(2R)-2,3-BIS(OXIDANYL)PROPANOATE'>MPG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=VIS:2-CHLORANYL-~{N}-(4-CHLORANYL-3-PYRIDIN-2-YL-PHENYL)-4-METHYLSULFONYL-BENZAMIDE'>VIS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7i OCA], [http://pdbe.org/5l7i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7i RCSB], [http://www.ebi.ac.uk/pdbsum/5l7i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7i ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Covey, D F]]
+[[Category: Eamon, F X.B]]
+[[Category: Hedger, G]]
+[[Category: Luchetti, G]]
+[[Category: Miller, P S]]
+[[Category: Mydock-McGrane, L]]
+[[Category: Nachtergaele, S]]
+[[Category: Newstead, S]]
+[[Category: Rambo, R F]]
+[[Category: Rohatgi, R]]
+[[Category: Sansom, M S.P]]
+[[Category: Siebold, C]]
+[[Category: Sircar, R]]
+[[Category: Tully, M D]]
+[[Category: G protein coupled receptor]]
+[[Category: Hedgehog signaling]]
+[[Category: Membrane protein]]
+[[Category: Morphogen signaling]]
+[[Category: Signaling protein]]