Plasminogen: Difference between revisions
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<StructureSection load='4dur' size='350' side='right' caption='Human glycosylated plasminogen complex with acetate, bicarbonate, K+ and Cl- ions (PDB entry [[4dur]])' scene=''> | |||
== Function == | == Function == | ||
'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. | '''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. | ||
*'''Microplasmin''' induces posterior vitreous detachment from the retina (PVD)<ref>PMID:21099453</ref>. | |||
== Disease == | == Disease == | ||
PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces<ref>PMID:19141167</ref>. | PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces<ref>PMID:19141167</ref>. | ||
== Structural highlights == | |||
PLN contains 7 domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues. The kringle domain folds into a large loop containing 3 disulfide bonds. The kringle domain is important in protein-protein interaction with blood coagulation factors.<ref>PMID:22832192</ref>. | |||
</StructureSection> | |||
== 3D Structures of plasminogen == | == 3D Structures of plasminogen == | ||
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*Plasminogen | *Plasminogen | ||
**[[4dur]], [[4duu]], [[4a5t]] – hPLG 2 | **[[4dur]], [[4duu]], [[4a5t]] – hPLG 2 - human | ||
*Plasminogen kringle 1 | *Plasminogen kringle 1 | ||
**[[1pkr]] - hPLG kringle 1 | **[[1pkr]] - hPLG kringle 1 <BR /> | ||
**[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | **[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR /> | ||
**[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | **[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR /> | ||
