5jyp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5jyp is ~~ON HOLD until Paper Publication~~

==Allosteric inhibition of Kidney Isoform of Glutaminase==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5jyp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYP OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYP FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZBS:2-PHENYL-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-PHENYLETHANOYLAMINO)-1,3,4-THIADIAZOL-2-YL]CYCLOHEXYL]-1,3,4-THIADIAZOL-2-YL]ETHANAMIDE'>ZBS</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5jyo|5jyo]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyp OCA], [http://pdbe.org/5jyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyp RCSB], [http://www.ebi.ac.uk/pdbsum/5jyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyp ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.

__TOC__

</StructureSection>

[[Category: Glutaminase]]

[[Category: Ramachandran, S]]

[[Category: Sivaraman, J]]

[[Category: Allosteric inhibition]]

[[Category: Gac]]

[[Category: Hydrolase]]

[[Category: Kga]]

[[Category: Warburg effect]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5jyp is ON HOLD  until Paper Publication
+==Allosteric inhibition of Kidney Isoform of Glutaminase==
+<StructureSection load='5jyp' size='340' side='right' caption='[[5jyp]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5jyp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYP FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZBS:2-PHENYL-~{N}-[5-[(1~{S},3~{S})-3-[5-(2-PHENYLETHANOYLAMINO)-1,3,4-THIADIAZOL-2-YL]CYCLOHEXYL]-1,3,4-THIADIAZOL-2-YL]ETHANAMIDE'>ZBS</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jyo|5jyo]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyp OCA], [http://pdbe.org/5jyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyp RCSB], [http://www.ebi.ac.uk/pdbsum/5jyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN]] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity.
+__TOC__
+</StructureSection>
+[[Category: Glutaminase]]
+[[Category: Ramachandran, S]]
+[[Category: Sivaraman, J]]
+[[Category: Allosteric inhibition]]
+[[Category: Gac]]
+[[Category: Hydrolase]]
+[[Category: Kga]]
+[[Category: Warburg effect]]