5kdo: Difference between revisions

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'''Unreleased structure'''


The entry 5kdo is ON HOLD  until Paper Publication
==Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1==
 
<StructureSection load='5kdo' size='340' side='right' caption='[[5kdo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5kdo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KDO FirstGlance]. <br>
Description: Heterotrimeric complex of the 4 alanine insertion variant of the Gi alpha1 subunit and the Gbeta1-Ggamma1
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kdl|5kdl]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdo OCA], [http://pdbe.org/5kdo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdo RCSB], [http://www.ebi.ac.uk/pdbsum/5kdo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdo ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>  [[http://www.uniprot.org/uniprot/GBG1_BOVIN GBG1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gilbert, J]]
[[Category: Gilbert, J]]
[[Category: Lokits, A.D]]
[[Category: Hamm, H E]]
[[Category: Iverson, T M]]
[[Category: Kaya, A I]]
[[Category: Lokits, A D]]
[[Category: Meiler, J]]
[[Category: Meiler, J]]
[[Category: Iverson, T.M]]
[[Category: Heterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release]]
[[Category: Hamm, H.E]]
[[Category: Signaling protein]]
[[Category: Kaya, A.I]]
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