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'''Crystal structure of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase''' | '''Crystal structure of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase''' | ||
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[[Category: Park, H U.]] | [[Category: Park, H U.]] | ||
[[Category: Strynadka, N C.J.]] | [[Category: Strynadka, N C.J.]] | ||
[[Category: | [[Category: Beta-lactamase inhibitor protein-ii]] | ||
[[Category: | [[Category: Blip-ii]] | ||
[[Category: | [[Category: Protein-protein complex]] | ||
[[Category: | [[Category: Tem-1 beta-lactamase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:53:40 2008'' | |||
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Revision as of 18:53, 2 May 2008
Crystal structure of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase
Overview
The structure of the 28 kDa beta-lactamase inhibitor protein-II (BLIP-II) in complex with the TEM-1 beta-lactamase has been determined to 2.3 A resolution. BLIP-II is a secreted protein produced by the soil bacterium Streptomyces exfoliatus SMF19 and is able to bind and inhibit TEM-1 with subnanomolar affinity. BLIP-II is a seven-bladed beta-propeller with a unique blade motif consisting of only three antiparallel beta-strands. The overall fold is highly similar to the core structure of the human regulator of chromosome condensation (RCC1). Although BLIP-II does not share the same fold with BLIP, the first beta-lactamase inhibitor protein for which structural data was available, a comparison of the two complexes reveals a number of similarities and provides further insights into key components of the TEM-1-BLIP and TEM-1-BLIP-II interfaces. Our preliminary results from gene knock-out studies and scanning electron microscopy also reveal a critical role of BLIP-II in sporulation.
About this Structure
1JTD is a Protein complex structure of sequences from Escherichia coli and Streptomyces exfoliatus. Full crystallographic information is available from OCA.
Reference
Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase., Lim D, Park HU, De Castro L, Kang SG, Lee HS, Jensen S, Lee KJ, Strynadka NC, Nat Struct Biol. 2001 Oct;8(10):848-52. PMID:11573088 Page seeded by OCA on Fri May 2 21:53:40 2008
