5hin: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5hin is ~~ON HOLD until Jul 20 2017~~

==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound==

~~Authors~~: ~~Huang~~, J., Wu, D., Lu, Q., ~~Yao, X~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5hin]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HIN OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HIN FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~human dihydroorotate dehydrogenase~~ (~~DHODH~~) ~~with 18L compound~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1KL:METHYL+(2Z)-(3-{4-[(4-TERT-BUTYLPHENYL)CARBAMOYL]PHENYL}-4-OXO-1,3-THIAZOLIDIN-2-YLIDENE)(CYANO)ACETATE'>1KL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hin OCA], [http://pdbe.org/5hin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hin RCSB], [http://www.ebi.ac.uk/pdbsum/5hin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hin ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

== Function ==

[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

== References ==

__TOC__

</StructureSection>

[[Category: Huang, J]]

[[Category: Lu, Q]]

[[Category: Wu, D]]

[[Category: Yao, X]]

[[Category: ~~Lu, Q~~]]

[[Category: Inhibitor]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5hin is ON HOLD  until Jul 20 2017
+==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound==
+<StructureSection load='5hin' size='340' side='right' caption='[[5hin]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Huang, J., Wu, D., Lu, Q., Yao, X.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5hin]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HIN FirstGlance]. <br>
-Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1KL:METHYL+(2Z)-(3-{4-[(4-TERT-BUTYLPHENYL)CARBAMOYL]PHENYL}-4-OXO-1,3-THIAZOLIDIN-2-YLIDENE)(CYANO)ACETATE'>1KL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hin OCA], [http://pdbe.org/5hin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hin RCSB], [http://www.ebi.ac.uk/pdbsum/5hin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hin ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Huang, J]]
+[[Category: Lu, Q]]
 [[Category: Wu, D]]
 [[Category: Yao, X]]
-[[Category: Lu, Q]]
+[[Category: Inhibitor]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]