5kb3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5kb3 is ~~ON HOLD until Paper Publication~~

==1.4 A resolution structure of Helicobacter Pylori MTAN in complexed with p-ClPh-DADMe-ImmA==

~~Authors~~: ~~Banco~~, M.T., ~~Ronning~~, D.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[5kb3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KB3 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KB3 FirstGlance].

~~Description~~: 1.~~4 A resolution structure~~ of Helicobacter ~~Pylori MTAN~~ in ~~complexed with p~~-~~ClPh~~-~~DADMe~~-~~ImmA~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=4CT:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-{[(4-CHLOROPHENYL)SULFANYL]METHYL}PYRROLIDIN-3-OL'>4CT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

[[Category: Ronning, D.R]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kb3 OCA], [http://pdbe.org/5kb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kb3 RCSB], [http://www.ebi.ac.uk/pdbsum/5kb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kb3 ProSAT]</td></tr>

[[Category: ~~Banco, M.T~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ]] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Banco, M T]]

[[Category: Ronning, D R]]

[[Category: Helicobacter pylori]]

[[Category: Hydrolase]]

[[Category: Neutron crystallography]]

[[Category: Nucleosidase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5kb3 is ON HOLD  until Paper Publication
+==1.4 A resolution structure of Helicobacter Pylori MTAN in complexed with p-ClPh-DADMe-ImmA==
+<StructureSection load='5kb3' size='340' side='right' caption='[[5kb3]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors: Banco, M.T., Ronning, D.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5kb3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KB3 FirstGlance]. <br>
-Description: 1.4 A resolution structure of Helicobacter Pylori MTAN in complexed with p-ClPh-DADMe-ImmA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CT:(3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-{[(4-CHLOROPHENYL)SULFANYL]METHYL}PYRROLIDIN-3-OL'>4CT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ccd|5ccd]], [[5cce|5cce]], [[5jpc|5jpc]], [[5k1z|5k1z]]</td></tr>
-[[Category: Ronning, D.R]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kb3 OCA], [http://pdbe.org/5kb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kb3 RCSB], [http://www.ebi.ac.uk/pdbsum/5kb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kb3 ProSAT]</span></td></tr>
-[[Category: Banco, M.T]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ]] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Banco, M T]]
+[[Category: Ronning, D R]]
+[[Category: Helicobacter pylori]]
+[[Category: Hydrolase]]
+[[Category: Neutron crystallography]]
+[[Category: Nucleosidase]]