5kp2: Difference between revisions

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'''Unreleased structure'''


The entry 5kp2 is ON HOLD
==Beta-ketoacyl-ACP synthase III -2 (FabH2) (C113A) from Vibrio Cholerae cocrystallized with octanoyl-CoA: hydrolzed ligand==
 
<StructureSection load='5kp2' size='340' side='right' caption='[[5kp2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
Authors: Hou, J., Zheng, H., Grabowski, M., Anderson, W.F., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5kp2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KP2 FirstGlance]. <br>
Description: Beta-ketoacyl-ACP synthase III -2 (FabH2) (C113A) from Vibrio Cholerae soaked with octanoyl-CoA: hydrolzed ligand
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=OCA:OCTANOIC+ACID+(CAPRYLIC+ACID)'>OCA</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kp2 OCA], [http://pdbe.org/5kp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kp2 RCSB], [http://www.ebi.ac.uk/pdbsum/5kp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kp2 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FABH2_VIBCH FABH2_VIBCH]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.[HAMAP-Rule:MF_01815]
__TOC__
</StructureSection>
[[Category: Anderson, W F]]
[[Category: Structural genomic]]
[[Category: Grabowski, M]]
[[Category: Hou, J]]
[[Category: Minor, W]]
[[Category: Zheng, H]]
[[Category: Zheng, H]]
[[Category: Minor, W]]
[[Category: Beta-ketoacyl-acyl carrier protein synthase iii]]
[[Category: Hou, J]]
[[Category: Csgid]]
[[Category: Anderson, W.F]]
[[Category: Fabh]]
[[Category: Grabowski, M]]
[[Category: Transferase]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
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