1k1a: Difference between revisions
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{{STRUCTURE_1k1a| PDB=1k1a | SCENE= }} | |||
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'''Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family''' | '''Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family''' | ||
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[[Category: Siebenlist, U.]] | [[Category: Siebenlist, U.]] | ||
[[Category: Soler-Lopez, M.]] | [[Category: Soler-Lopez, M.]] | ||
[[Category: | [[Category: Bcl-3]] | ||
[[Category: | [[Category: Ikappab protein]] | ||
[[Category: | [[Category: Nf-kappab transcription factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:10:31 2008'' | |||
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Revision as of 19:10, 2 May 2008
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family
Overview
IkappaB proteins associate with the transcription factor NF-kappaB via their ankyrin repeat domain. Bcl-3 is an unusual IkappaB protein because it is primarily nucleoplasmic and can lead to enhanced NF-kappaB-dependent transcription, unlike the prototypical IkappaB protein IkappaBalpha, which inhibits NF-kappaB activity by retaining it in the cytoplasm. Here we report the 1.9 A crystal structure of the ankyrin repeat domain of human Bcl-3 and compare it with that of IkappaBalpha bound to NF-kappaB. The two structures are highly similar over the central ankyrin repeats but differ in the N-terminal repeat and at the C-terminus, where Bcl-3 contains a seventh repeat in place of the acidic PEST region of IkappaBalpha. Differences between the two structures suggest why Bcl-3 differs from IkappaBalpha in selectivity towards various NF-kappaB species, why Bcl-3 but not IkappaBalpha can associate with its NF-kappaB partner bound to DNA, and why two molecules of Bcl-3 but only one of IkappaBalpha can bind to its NF-kappaB partner. Comparison of the two structures thus provides an insight into the functional diversity of IkappaB proteins.
About this Structure
1K1A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family., Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Muller CW, EMBO J. 2001 Nov 15;20(22):6180-90. PMID:11707390 Page seeded by OCA on Fri May 2 22:10:31 2008
