1k1s: Difference between revisions
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'''Crystal Structure of DinB from Sulfolobus solfataricus''' | '''Crystal Structure of DinB from Sulfolobus solfataricus''' | ||
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[[Category: Toth, E A.]] | [[Category: Toth, E A.]] | ||
[[Category: 4-stranded antiparallel b-sheet]] | [[Category: 4-stranded antiparallel b-sheet]] | ||
[[Category: | [[Category: Mixed a/b structure]] | ||
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Revision as of 19:11, 2 May 2008
Crystal Structure of DinB from Sulfolobus solfataricus
Overview
A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 A resolution crystal structure of the Sulfolobus solfataricus Dbh protein, a DNA translesion polymerase closely related to Escherichia coli DNA polymerase IV and human polymerase kappa. A high error rate is observed for the Dbh polymerase in a range of 10(-2)-10(-3) for all 12 base substitution mispairs. The crystal structure of Dbh reveals an overall architecture resembling other DNA polymerases but has unique features that are likely to contribute to error-prone synthesis, including -1 frameshifting mutations.
About this Structure
1K1S is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:11685247 Page seeded by OCA on Fri May 2 22:11:35 2008
