5kvm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5kvm is ~~ON HOLD~~

==Extracellular region of mouse GPR56/ADGRG1 in complex with FN3 monobody==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5kvm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KVM FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kvm OCA], [http://pdbe.org/5kvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kvm RCSB], [http://www.ebi.ac.uk/pdbsum/5kvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kvm ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AGRG1_MOUSE AGRG1_MOUSE]] Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development (PubMed:20981830).[UniProtKB:Q9Y653]<ref>PMID:18378689</ref> <ref>PMID:18509043</ref> <ref>PMID:19515912</ref> <ref>PMID:20981830</ref> <ref>PMID:21768377</ref> <ref>PMID:23478665</ref> <ref>PMID:24531968</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arac, D]]

[[Category: Ding, C]]

[[Category: Koide, S]]

[[Category: Salzman, G S]]

[[Category: Adhesion-gpcr]]

[[Category: Cell adhesion]]

[[Category: Gain]]

[[Category: Monobody]]

[[Category: Pll]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5kvm is ON HOLD
+==Extracellular region of mouse GPR56/ADGRG1 in complex with FN3 monobody==
+<StructureSection load='5kvm' size='340' side='right' caption='[[5kvm]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5kvm]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KVM FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kvm OCA], [http://pdbe.org/5kvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kvm RCSB], [http://www.ebi.ac.uk/pdbsum/5kvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kvm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AGRG1_MOUSE AGRG1_MOUSE]] Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (PubMed:21768377). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (PubMed:23478665). Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development (PubMed:20981830).[UniProtKB:Q9Y653]<ref>PMID:18378689</ref> <ref>PMID:18509043</ref> <ref>PMID:19515912</ref> <ref>PMID:20981830</ref> <ref>PMID:21768377</ref> <ref>PMID:23478665</ref> <ref>PMID:24531968</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arac, D]]
+[[Category: Ding, C]]
+[[Category: Koide, S]]
+[[Category: Salzman, G S]]
+[[Category: Adhesion-gpcr]]
+[[Category: Cell adhesion]]
+[[Category: Gain]]
+[[Category: Monobody]]
+[[Category: Pll]]