1k64: Difference between revisions
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'''NMR Structue of alpha-conotoxin EI''' | '''NMR Structue of alpha-conotoxin EI''' | ||
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==About this Structure== | ==About this Structure== | ||
1K64 is a [[Single protein]] structure | 1K64 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K64 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Park, K H.]] | [[Category: Park, K H.]] | ||
[[Category: Suk, J E.]] | [[Category: Suk, J E.]] | ||
[[Category: | [[Category: Omega-shaped containing a-helix]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:17 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 19:21, 2 May 2008
NMR Structue of alpha-conotoxin EI
Overview
A high resolution structure of alpha-conotoxin EI has been determined by (1)H NMR spectroscopy and molecular modeling. alpha-Conotoxin EI has the same disulfide framework as alpha 4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors but antagonizes the neuromuscular receptor as do the alpha 3/5 and alpha A conotoxins. The unique binding preference of alpha-conotoxin EI to the alpha(1)/delta subunit interface of Torpedo neuromuscular receptor makes it a valuable structural template for superposition of various alpha-conotoxins possessing distinct receptor subtype specificities. Structural comparison of alpha-conotoxin EI with the gamma-subunit favoring alpha-conotoxin GI suggests that the Torpedo delta-subunit preference of the former originates from its second loop. Superposition of three-dimensional structures of seven alpha-conotoxins reveals that the estimated size of the toxin-binding pocket in nicotinic acetylcholine receptor is approximately 20 A (height) x 20 A (width) x 15 A (thickness).
About this Structure
1K64 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptor., Park KH, Suk JE, Jacobsen R, Gray WR, McIntosh JM, Han KH, J Biol Chem. 2001 Dec 28;276(52):49028-33. Epub 2001 Oct 18. PMID:11641403 Page seeded by OCA on Fri May 2 22:21:17 2008
