1k78: Difference between revisions

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[[Image:1k78.gif|left|200px]]
[[Image:1k78.gif|left|200px]]


{{Structure
<!--
|PDB= 1k78 |SIZE=350|CAPTION= <scene name='initialview01'>1k78</scene>, resolution 2.25&Aring;
The line below this paragraph, containing "STRUCTURE_1k78", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= PAX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ETS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
-->
|DOMAIN=
{{STRUCTURE_1k78|  PDB=1k78 |  SCENE= }}  
|RELATEDENTRY=[[1k79|1K79]], [[1k7a|1K7A]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k78 OCA], [http://www.ebi.ac.uk/pdbsum/1k78 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k78 RCSB]</span>
}}


'''Pax5(1-149)+Ets-1(331-440)+DNA'''
'''Pax5(1-149)+Ets-1(331-440)+DNA'''
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[[Category: Hagman, J.]]
[[Category: Hagman, J.]]
[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
[[Category: ets domain]]
[[Category: Ets domain]]
[[Category: paired domain]]
[[Category: Paired domain]]
[[Category: transcription factor]]
[[Category: Transcription factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:23:33 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:26 2008''

Revision as of 19:23, 2 May 2008

File:1k78.gif

Template:STRUCTURE 1k78

Pax5(1-149)+Ets-1(331-440)+DNA


Overview

Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.

Disease

Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]

About this Structure

1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502 Page seeded by OCA on Fri May 2 22:23:33 2008

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