5kwn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 5kwn is ~~ON HOLD~~ ~~until Paper Publication~~

==The WD domain ofArabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from HY5==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5kwn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KWN FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwn OCA], [http://pdbe.org/5kwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kwn RCSB], [http://www.ebi.ac.uk/pdbsum/5kwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwn ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/COP1_ARATH COP1_ARATH]] E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways.<ref>PMID:11967090</ref> <ref>PMID:12023303</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Blacklow, S]]

[[Category: Uljon, S]]

[[Category: Ligase-peptide complex]]

[[Category: Photomorphogenesis e3 ligase wd domain transcription factor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5kwn is ON HOLD  until Paper Publication
+==The WD domain ofArabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from HY5==
+<StructureSection load='5kwn' size='340' side='right' caption='[[5kwn]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5kwn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KWN FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwn OCA], [http://pdbe.org/5kwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kwn RCSB], [http://www.ebi.ac.uk/pdbsum/5kwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwn ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/COP1_ARATH COP1_ARATH]] E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways.<ref>PMID:11967090</ref> <ref>PMID:12023303</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Blacklow, S]]
+[[Category: Uljon, S]]
+[[Category: Ligase-peptide complex]]
+[[Category: Photomorphogenesis e3 ligase wd domain transcription factor]]