1kaw: Difference between revisions
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'''STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)''' | '''STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)''' | ||
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[[Category: Raghunathan, S.]] | [[Category: Raghunathan, S.]] | ||
[[Category: Waksman, G.]] | [[Category: Waksman, G.]] | ||
[[Category: | [[Category: Dna-binding protein]] | ||
[[Category: | [[Category: Single stranded dna binding protein]] | ||
[[Category: | [[Category: Ssb]] | ||
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Revision as of 19:31, 2 May 2008
STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)
Overview
The crystal structure of the tetrameric DNA-binding domain of the single-stranded DNA binding protein from Escherichia coli was determined at a resolution of 2.9 A using multiwavelength anomalous dispersion. Each monomer in the tetramer is topologically similar to an oligomer-binding fold. Two monomers each contribute three beta-strands to a single six-stranded beta-sheet to form a dimer. Two dimer-dimer interfaces are observed within the crystal. One of these stabilizes the tetramer in solution. The other interface promotes a superhelical structure within the crystal that may reflect tetramer-tetramer interactions involved in the positive cooperative binding of the single-stranded DNA-binding protein to single-stranded DNA.
About this Structure
1KAW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution., Raghunathan S, Ricard CS, Lohman TM, Waksman G, Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6652-7. PMID:9192620 Page seeded by OCA on Fri May 2 22:31:07 2008
