Pteridine reductase: Difference between revisions
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== Relevance == | == Relevance == | ||
PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. | PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs<ref>PMID:18245389</ref>. | ||
== Structural highlights == | |||
Six residues are important for creating the active site, substrate binding or implicated in catalysis<ref>PMID:16055151</ref>. | |||
</StructureSection> | </StructureSection> | ||
