5gov: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5gov is ~~ON HOLD~~

==Crystal Structure of MCR-1, a phosphoethanolamine transferase, extracellular domain==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5gov]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOV OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GOV FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gov OCA], [http://pdbe.org/5gov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gov RCSB], [http://www.ebi.ac.uk/pdbsum/5gov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gov ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX]] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Chen, S]]

[[Category: Guo, J]]

[[Category: Hao, Q]]

[[Category: Hu, M]]

[[Category: Colistin]]

[[Category: Mcr-1]]

[[Category: Petn transferase]]

[[Category: Phosphorylation]]

[[Category: Transferase]]

[[Category: Zinc-binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5gov is ON HOLD
+==Crystal Structure of MCR-1, a phosphoethanolamine transferase, extracellular domain==
+<StructureSection load='5gov' size='340' side='right' caption='[[5gov]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5gov]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GOV FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gov OCA], [http://pdbe.org/5gov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gov RCSB], [http://www.ebi.ac.uk/pdbsum/5gov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gov ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX]] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref>   Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chen, S]]
+[[Category: Guo, J]]
+[[Category: Hao, Q]]
+[[Category: Hu, M]]
+[[Category: Colistin]]
+[[Category: Mcr-1]]
+[[Category: Petn transferase]]
+[[Category: Phosphorylation]]
+[[Category: Transferase]]
+[[Category: Zinc-binding]]