5lkl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5lkl is ~~ON HOLD~~

==Crystal Structure of full-lengh CSFV NS3/4A==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5lkl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LKL FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lkl OCA], [http://pdbe.org/5lkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lkl RCSB], [http://www.ebi.ac.uk/pdbsum/5lkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lkl ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539]

__TOC__

</StructureSection>

[[Category: Rey, F A]]

[[Category: Tortorici, M A]]

[[Category: Viral protease/helicase with its cofactor]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5lkl is ON HOLD
+==Crystal Structure of full-lengh CSFV NS3/4A==
+<StructureSection load='5lkl' size='340' side='right' caption='[[5lkl]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5lkl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LKL FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lkl OCA], [http://pdbe.org/5lkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lkl RCSB], [http://www.ebi.ac.uk/pdbsum/5lkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lkl ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane.  P7 forms a leader sequence to properly orient NS2 in the membrane.  Uncleaved NS2-3 is required for production of infectious virus.  NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029]  NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.  NS4A is a cofactor for the NS3 protease activity.  RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539]
+__TOC__
+</StructureSection>
+[[Category: Rey, F A]]
+[[Category: Tortorici, M A]]
+[[Category: Viral protease/helicase with its cofactor]]
+[[Category: Viral protein]]