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==The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate.==
==The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate.==
<StructureSection load='4e5u' size='340' side='right' caption='[[4e5u]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='4e5u' size='340' side='right'caption='[[4e5u]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4e5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E5U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4e5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E5U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e5u OCA], [https://pdbe.org/4e5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e5u RCSB], [https://www.ebi.ac.uk/pdbsum/4e5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e5u ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA2962, tmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e5u OCA], [http://pdbe.org/4e5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e5u RCSB], [http://www.ebi.ac.uk/pdbsum/4e5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e5u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).  
[[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).


==See Also==
==See Also==
*[[Thymidylate kinase|Thymidylate kinase]]
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseae]]
[[Category: Large Structures]]
[[Category: DTMP kinase]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Jedrzejczak, R]]
[[Category: Jedrzejczak R]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Joachimiak, G]]
[[Category: Joachimiak G]]
[[Category: Structural genomic]]
[[Category: Sacchettini J]]
[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
[[Category: Tan K]]
[[Category: Sacchettini, J]]
[[Category: Tan, K]]
[[Category: Mcsg]]
[[Category: Mtbi]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]
[[Category: Transferase]]
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