3b12: Difference between revisions

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==Crystal Structure of the Fluoroacetate Dehalogenase D104 mutant from Burkholderia sp. FA1 in complex with fluoroacetate==
==Crystal Structure of the Fluoroacetate Dehalogenase D104 mutant from Burkholderia sp. FA1 in complex with fluoroacetate==
<StructureSection load='3b12' size='340' side='right' caption='[[3b12]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='3b12' size='340' side='right'caption='[[3b12]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b12]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bursp Bursp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B12 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b12]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bursp Bursp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B12 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y37|1y37]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y37|1y37]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fac-dex ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36773 BURSP])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fac-dex ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36773 BURSP])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Haloacetate_dehalogenase Haloacetate dehalogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.3 3.8.1.3] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Haloacetate_dehalogenase Haloacetate dehalogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.3 3.8.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b12 OCA], [http://pdbe.org/3b12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b12 RCSB], [http://www.ebi.ac.uk/pdbsum/3b12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b12 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b12 OCA], [https://pdbe.org/3b12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b12 RCSB], [https://www.ebi.ac.uk/pdbsum/3b12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DEHA_BURSP DEHA_BURSP]] Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has only very low activity towards chloroacetate.[REFERENCE:1]<ref>PMID:19218394</ref>   
[[https://www.uniprot.org/uniprot/DEHA_BURSP DEHA_BURSP]] Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has only very low activity towards chloroacetate.[REFERENCE:1]<ref>PMID:19218394</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Dehalogenase|Dehalogenase]]
*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Bursp]]
[[Category: Bursp]]
[[Category: Haloacetate dehalogenase]]
[[Category: Haloacetate dehalogenase]]
[[Category: Large Structures]]
[[Category: Hirotsu, K]]
[[Category: Hirotsu, K]]
[[Category: Omi, R]]
[[Category: Omi, R]]
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