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==Crystal structure of Autophagic E2, Atg10==
==Crystal structure of Autophagic E2, Atg10==
<StructureSection load='4ebr' size='340' side='right' caption='[[4ebr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4ebr' size='340' side='right'caption='[[4ebr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ebr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EBR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ebr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EBR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ebr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebr OCA], [https://pdbe.org/4ebr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ebr RCSB], [https://www.ebi.ac.uk/pdbsum/4ebr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebr ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATG10, APG10, YLL042C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ebr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ebr OCA], [http://pdbe.org/4ebr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ebr RCSB], [http://www.ebi.ac.uk/pdbsum/4ebr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ebr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ATG10_YEAST ATG10_YEAST]] E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule.  
[[https://www.uniprot.org/uniprot/ATG10_YEAST ATG10_YEAST]] E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Autophagy-related protein|Autophagy-related protein]]
*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Hong, S B]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Kim, B W]]
[[Category: Hong SB]]
[[Category: Kim, J H]]
[[Category: Kim BW]]
[[Category: Song, H K]]
[[Category: Kim JH]]
[[Category: Atg12]]
[[Category: Song HK]]
[[Category: Atg3]]
[[Category: Atg5]]
[[Category: Atg7]]
[[Category: Autophagy]]
[[Category: E2-conjugating enzyme]]
[[Category: Ligase]]
[[Category: Protein binding]]
[[Category: Thiolation]]
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