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==Bifunctional tRNA modification enzyme MnmC from Escherichia coli==
==Bifunctional tRNA modification enzyme MnmC from Escherichia coli==
<StructureSection load='3awi' size='340' side='right' caption='[[3awi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3awi' size='340' side='right'caption='[[3awi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3awi]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AWI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3awi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AWI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mnmC, yfcK, b2324, JW5380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mnmC, yfcK, b2324, JW5380 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3awi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3awi OCA], [http://pdbe.org/3awi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3awi RCSB], [http://www.ebi.ac.uk/pdbsum/3awi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3awi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3awi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3awi OCA], [https://pdbe.org/3awi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3awi RCSB], [https://www.ebi.ac.uk/pdbsum/3awi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3awi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MNMC_ECOLI MNMC_ECOLI]] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.<ref>PMID:15247431</ref> <ref>PMID:18186482</ref>   
[[https://www.uniprot.org/uniprot/MNMC_ECOLI MNMC_ECOLI]] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.<ref>PMID:15247431</ref> <ref>PMID:18186482</ref>   
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Bessho, Y]]
[[Category: Bessho, Y]]
[[Category: Kitamura, A]]
[[Category: Kitamura, A]]
Retrieved from "https://proteopedia.org/3awi"