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==Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet, 6-carboxy-5,6,7,8-tetrahydropterin, and Mg2+==
==Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet, 6-carboxy-5,6,7,8-tetrahydropterin, and Mg2+==
<StructureSection load='4nji' size='340' side='right' caption='[[4nji]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4nji' size='340' side='right'caption='[[4nji]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nji]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burm1 Burm1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_multivorans_ATCC_17616 Burkholderia multivorans ATCC 17616]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NJI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2K8:(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPTERIDINE-6-CARBOXYLIC+ACID'>2K8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2K8:(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPTERIDINE-6-CARBOXYLIC+ACID'>2K8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4njg|4njg]], [[4njh|4njh]], [[4njj|4njj]], [[4njk|4njk]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nji OCA], [https://pdbe.org/4nji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nji RCSB], [https://www.ebi.ac.uk/pdbsum/4nji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nji ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">queE, Bmul_3115, BMULJ_00116 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=395019 BURM1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/7-carboxy-7-deazaguanine_synthase 7-carboxy-7-deazaguanine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.99.3 4.3.99.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nji OCA], [http://pdbe.org/4nji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nji RCSB], [http://www.ebi.ac.uk/pdbsum/4nji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nji ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A9AC61_BURM1 A9AC61_BURM1]] Catalyzes the conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity).[HAMAP-Rule:MF_00917]  
[https://www.uniprot.org/uniprot/QUEE_BURM1 QUEE_BURM1] Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.[HAMAP-Rule:MF_00917]<ref>PMID:24362703</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 7-carboxy-7-deazaguanine synthase]]
[[Category: Burkholderia multivorans ATCC 17616]]
[[Category: Burm1]]
[[Category: Large Structures]]
[[Category: Bandarian, V]]
[[Category: Bandarian V]]
[[Category: Bruender, N A]]
[[Category: Bruender NA]]
[[Category: Dowling, D P]]
[[Category: Dowling DP]]
[[Category: Drennan, C L]]
[[Category: Drennan CL]]
[[Category: McCarty, R M]]
[[Category: McCarty RM]]
[[Category: Young, A P]]
[[Category: Young AP]]
[[Category: Adomet radical enzyme]]
[[Category: Lyase]]
[[Category: Modified partial tim barrel-like structure]]
[[Category: Radical adomet fold]]
[[Category: Radical sam fold]]
[[Category: Synthase]]
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