4gaz: Difference between revisions
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==Crystal Structure of a Jumonji Domain-containing Protein JMJD5== | ==Crystal Structure of a Jumonji Domain-containing Protein JMJD5== | ||
<StructureSection load='4gaz' size='340' side='right' caption='[[4gaz]], [[Resolution|resolution]] 2.81Å' scene=''> | <StructureSection load='4gaz' size='340' side='right'caption='[[4gaz]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4gaz]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4gaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAZ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaz OCA], [https://pdbe.org/4gaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gaz RCSB], [https://www.ebi.ac.uk/pdbsum/4gaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaz ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. | ||
==See Also== | ==See Also== | ||
*[[Jumonji domain-containing protein|Jumonji domain-containing protein]] | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Tao | [[Category: Chen N]] | ||
[[Category: Wang | [[Category: Tao Y]] | ||
[[Category: Zang | [[Category: Wang H]] | ||
[[Category: Zhang | [[Category: Zang J]] | ||
[[Category: Zhou | [[Category: Zhang X]] | ||
[[Category: Zhou X]] | |||
Revision as of 06:45, 26 October 2022
Crystal Structure of a Jumonji Domain-containing Protein JMJD5
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