4wgi: Difference between revisions
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==A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)== | ==A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)== | ||
<StructureSection load='4wgi' size='340' side='right' caption='[[4wgi]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='4wgi' size='340' side='right'caption='[[4wgi]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4wgi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WGI FirstGlance]. <br> | <table><tr><td colspan='2'>[[4wgi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WGI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M6:(2S)-2-[(2S,3R)-10-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-3-METHYL-2-[(METHYL{[4-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)METHYL]-6-OXO-3,4-DIHYDRO-2H-1,5-BENZOXAZOCIN-5(6H)-YL]PROPANOIC+ACID'>3M6</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M6:(2S)-2-[(2S,3R)-10-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-3-METHYL-2-[(METHYL{[4-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)METHYL]-6-OXO-3,4-DIHYDRO-2H-1,5-BENZOXAZOCIN-5(6H)-YL]PROPANOIC+ACID'>3M6</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgi OCA], [http://pdbe.org/4wgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wgi RCSB], [http://www.ebi.ac.uk/pdbsum/4wgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wgi ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wgi OCA], [http://pdbe.org/4wgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wgi RCSB], [http://www.ebi.ac.uk/pdbsum/4wgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wgi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4wgi" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4wgi" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Clifton, M C]] | [[Category: Clifton, M C]] | ||
[[Category: Fairman, J W]] | [[Category: Fairman, J W]] | ||
Revision as of 08:04, 23 May 2019
A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)
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