4okg: Difference between revisions
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==LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid== | ==LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid== | ||
<StructureSection load='4okg' size='340' side='right' caption='[[4okg]], [[Resolution|resolution]] 2.06Å' scene=''> | <StructureSection load='4okg' size='340' side='right'caption='[[4okg]], [[Resolution|resolution]] 2.06Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4okg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKG FirstGlance]. <br> | <table><tr><td colspan='2'>[[4okg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKG FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2SZ:6-(1H-BENZIMIDAZOL-1-YL)-N-HYDROXY-5-[4-({6-[(4-METHYLPIPERAZIN-1-YL)METHYL]PYRIDIN-3-YL}ETHYNYL)PHENYL]PYRIDINE-3-CARBOXAMIDE'>2SZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2SZ:6-(1H-BENZIMIDAZOL-1-YL)-N-HYDROXY-5-[4-({6-[(4-METHYLPIPERAZIN-1-YL)METHYL]PYRIDIN-3-YL}ETHYNYL)PHENYL]PYRIDINE-3-CARBOXAMIDE'>2SZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">envA, lpxC, PA4406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okg OCA], [http://pdbe.org/4okg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okg RCSB], [http://www.ebi.ac.uk/pdbsum/4okg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okg OCA], [http://pdbe.org/4okg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okg RCSB], [http://www.ebi.ac.uk/pdbsum/4okg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | [[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | ||
==See Also== | |||
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Pseae]] | |||
[[Category: Lahiri, S D]] | [[Category: Lahiri, S D]] | ||
[[Category: Olivier, N B]] | [[Category: Olivier, N B]] | ||
